GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs6477998 | 1 | rs10759636 | chr9:116018777 | CDC26 | chr9:116029290-116037869:- | -0.36 | -5.77 | 9.96E-8 | Hematology traits |
| THYM | cis | rs881375 | 1 | rs10760118 | chr9:123641616 | LOC253039 | chr9:123605320-123616644:+ | -0.59 | -5.33 | 6.59E-7 | Rheumatoid arthritis |
| THYM | cis | rs881375 | 1 | rs10760121 | chr9:123647915 | LOC253039 | chr9:123605320-123616644:+ | -0.62 | -5.56 | 2.51E-7 | Rheumatoid arthritis |
| THYM | cis | rs7849270 | 1 | rs10760589 | chr9:131906293 | CRAT | chr9:131857075-131873070:- | 0.38 | 4.61 | 1.24E-5 | Blood metabolite ratios |
| THYM | cis | rs7301826 | 1 | rs10773819 | chr12:131279022 | STX2 | chr12:131274149-131323811:- | 0.35 | 5.91 | 5.25E-8 | Plasma plasminogen activator levels |
| THYM | cis | rs7301826 | 1 | rs10773822 | chr12:131289107 | STX2 | chr12:131274149-131323811:- | 0.35 | 5.89 | 5.79E-8 | Plasma plasminogen activator levels |
| THYM | cis | rs703842 | 1 | rs10783847 | chr12:58196447 | FAM119B | chr12:58166383-58176323:+ | 0.41 | 5.83 | 7.7E-8 | Multiple sclerosis |
| THYM | cis | rs703842 | 1 | rs10783847 | chr12:58196447 | TSFM | chr12:58176536-58191367:+ | -0.28 | -5.16 | 1.33E-6 | Multiple sclerosis |
| THYM | cis | rs703842 | 1 | rs10783848 | chr12:58196528 | FAM119B | chr12:58166383-58176323:+ | 0.41 | 5.83 | 7.7E-8 | Multiple sclerosis |
| THYM | cis | rs703842 | 1 | rs10783848 | chr12:58196528 | TSFM | chr12:58176536-58191367:+ | -0.28 | -5.16 | 1.33E-6 | Multiple sclerosis |
| THYM | cis | rs2275426 | 1 | rs10789475 | chr1:46304177 | CCDC163P | chr1:45960581-45965646:- | -0.48 | -5.58 | 2.24E-7 | Body mass index |
| THYM | cis | rs2275426 | 1 | rs10789481 | chr1:46383583 | CCDC163P | chr1:45960581-45965646:- | -0.48 | -5.73 | 1.2E-7 | Body mass index |
| THYM | cis | rs2275426 | 1 | rs10789487 | chr1:46420221 | CCDC163P | chr1:45960581-45965646:- | -0.49 | -6 | 3.55E-8 | Body mass index |
| THYM | cis | rs2564921 | 1 | rs1078968 | chr3:53123486 | RFT1 | chr3:53122503-53164470:- | -0.44 | -4.93 | 3.42E-6 | Height |
| THYM | cis | rs568617 | 1 | rs10791830 | chr11:65661291 | CTSW | chr11:65647284-65651212:+ | -0.56 | -5.87 | 6.24E-8 | Crohn's disease |